A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells

A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells

The transcription factor ThPOK promotes CD4+ T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4+ T lineage integrity and couples effector differentiation to environmental cues after antigenic stimulation. ThPOK pre...

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Bibliographic Details
Main Authors: Vacchio, Melanie S., Wang, Lie, Bouladoux, Nicolas, Carpenter, Andrea C., Xiong, Yumei, Williams, Linus C., Wohlfert, Elizabeth, Song, Ki-Duk, Belkaid, Yasmine, Love, Paul E., Bosselut, Rémy
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251968/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251968/

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