T cells expressing a LMP1-specific chimeric antigen receptor mediate antitumor effects against LMP1-positive nasopharyngeal carcinoma cells in vitro and in vivo

T cells expressing a LMP1-specific chimeric antigen receptor mediate antitumor effects against LMP1-positive nasopharyngeal carcinoma cells in vitro and in vivo

T cells modified with chimeric antigen receptor are an attractive strategy to treat Epstein-Barr virus (EBV) associated malignancies. The EBV latent membrane protein 1 (LMP1) is a 66-KD integral membrane protein encoded by EBV that consists of transmembrane-spanning loops. Previously, we have identi...

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Bibliographic Details
Main Authors: Tang, Xiaojun, Zhou, Yan, Li, Wenjie, Tang, Qi, Chen, Renjie, Zhu, Jin, Feng, Zhenqing
Format: Online
Language:English
Published: Editorial Department of Journal of Biomedical Research 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250525/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250525/

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