Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis

The aim of the present study was to investigate the correlation between apolipoprotein E (ApoE) gene polymorphisms and the occurrence of urolithiasis and dyslipidemia. A total of 180 Uyghur individuals, including 90 urolithiasis patients and 90 healthy controls, were enrolled in this study. The bloo...

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Main Authors:	QIAN, BIAO, ZHENG, LIYING, WANG, QINZHANG, DING, GUOFU
Format:	Online
Language:	English
Published:	D.A. Spandidos 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247315/

id	pubmed-4247315
recordtype	oai_dc
spelling	pubmed-42473152014-12-01 Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis QIAN, BIAO ZHENG, LIYING WANG, QINZHANG DING, GUOFU Articles The aim of the present study was to investigate the correlation between apolipoprotein E (ApoE) gene polymorphisms and the occurrence of urolithiasis and dyslipidemia. A total of 180 Uyghur individuals, including 90 urolithiasis patients and 90 healthy controls, were enrolled in this study. The blood lipid profiles of the patients and controls were investigated and compared, and the composition of the urinary calculi was determined. The polymorphisms of the ApoE alleles were analyzed using polymerase chain reaction-restriction fragment length polymorphism analysis. Three common genotypes of the ApoE gene, E3/3, E3/4 and E4/4, were detected in the urolithiasis patients and control group. In the patient group, 28 patients with the E3/3 genotype (30.1%), 58 patients with the E3/4 genotype (64.4%) and four patients with the E4/4 genotype (4.5%) were identified. By contrast, in the control group, 52 patients with the E3/3 genotype (57.8%), 35 patients with the E3/4 genotype (38.9%) and three patients with the E4/4 genotype (3.3%) were identified. The frequency of the E3/4 genotype was found to be significantly higher in the patient group when compared with the control group (χ2=12.96; P<0.001). In addition, the frequency of the E4 allele was significantly higher in the patient group when compared with the control group (χ2= 6.61; P=0.025). In conclusion, the occurrence of urolithiasis was found to be associated with ApoE gene polymorphisms, and the E4 allele may be a potential susceptibility factor for urolithiasis. D.A. Spandidos 2015-01 2014-11-04 /pmc/articles/PMC4247315/ /pubmed/25452799 http://dx.doi.org/10.3892/etm.2014.2047 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	QIAN, BIAO ZHENG, LIYING WANG, QINZHANG DING, GUOFU
spellingShingle	QIAN, BIAO ZHENG, LIYING WANG, QINZHANG DING, GUOFU Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis
author_facet	QIAN, BIAO ZHENG, LIYING WANG, QINZHANG DING, GUOFU
author_sort	QIAN, BIAO
title	Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis
title_short	Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis
title_full	Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis
title_fullStr	Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis
title_full_unstemmed	Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis
title_sort	correlation between apoe gene polymorphisms and the occurrence of urolithiasis
description	The aim of the present study was to investigate the correlation between apolipoprotein E (ApoE) gene polymorphisms and the occurrence of urolithiasis and dyslipidemia. A total of 180 Uyghur individuals, including 90 urolithiasis patients and 90 healthy controls, were enrolled in this study. The blood lipid profiles of the patients and controls were investigated and compared, and the composition of the urinary calculi was determined. The polymorphisms of the ApoE alleles were analyzed using polymerase chain reaction-restriction fragment length polymorphism analysis. Three common genotypes of the ApoE gene, E3/3, E3/4 and E4/4, were detected in the urolithiasis patients and control group. In the patient group, 28 patients with the E3/3 genotype (30.1%), 58 patients with the E3/4 genotype (64.4%) and four patients with the E4/4 genotype (4.5%) were identified. By contrast, in the control group, 52 patients with the E3/3 genotype (57.8%), 35 patients with the E3/4 genotype (38.9%) and three patients with the E4/4 genotype (3.3%) were identified. The frequency of the E3/4 genotype was found to be significantly higher in the patient group when compared with the control group (χ2=12.96; P<0.001). In addition, the frequency of the E4 allele was significantly higher in the patient group when compared with the control group (χ2= 6.61; P=0.025). In conclusion, the occurrence of urolithiasis was found to be associated with ApoE gene polymorphisms, and the E4 allele may be a potential susceptibility factor for urolithiasis.
publisher	D.A. Spandidos
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247315/
_version_	1613161854836670464

Correlation between ApoE gene polymorphisms and the occurrence of urolithiasis

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