Monoclonal Antibody Targeting of Fibroblast Growth Factor Receptor 1c Ameliorates Obesity and Glucose Intolerance via Central Mechanisms

Monoclonal Antibody Targeting of Fibroblast Growth Factor Receptor 1c Ameliorates Obesity and Glucose Intolerance via Central Mechanisms

We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose control. R1c mAb also caused weight loss in leptin-...

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Bibliographic Details
Main Authors: Lelliott, Christopher J., Ahnmark, Andrea, Admyre, Therese, Ahlstedt, Ingela, Irving, Lorraine, Keyes, Feenagh, Patterson, Laurel, Mumphrey, Michael B., Bjursell, Mikael, Gorman, Tracy, Bohlooly-Y, Mohammad, Buchanan, Andrew, Harrison, Paula, Vaughan, Tristan, Berthoud, Hans-Rudolf, Lindén, Daniel
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245083/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245083/

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