DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth
DNA hypomethylation may activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-adenosylmethionine (SAM) is a methyl donor in numerous methylation reactions and acts as an inhibitor of intracellular demethylase activity, which results in hypermethylation of DNA. The m...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244666/ |