Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein

Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein

The influenza virus PB1 protein is the core subunit of the heterotrimeric polymerase complex (PA, PB1 and PB2) in which PB1 is responsible for catalyzing RNA polymerization and binding to the viral RNA promoter. Among the three subunits, PB1 is the least known subunit so far in terms of its structur...

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Bibliographic Details
Main Authors: Li, Chunfeng, Wu, Aiping, Peng, Yousong, Wang, Jingfeng, Guo, Yang, Chen, Zhigao, Zhang, Hong, Wang, Yongqiang, Dong, Jiuhong, Wang, Lulan, Qin, F. Xiao-Feng, Cheng, Genhong, Deng, Tao, Jiang, Taijiao
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244630/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244630/

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