Identification of Transglutaminase Reactive Residues in Human Osteopontin and Their Role in Polymerization

Osteopontin (OPN) is a highly posttranslationally modified protein present in several tissues where it is implicated in numerous physiological processes. OPN primarily exerts its functions through interaction with integrins via the Arg-Gly-Asp and Ser-Val-Val-Tyr-Gly-Leu-Arg sequences located in the...

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Main Authors: Christensen, Brian, Zachariae, Elias D., Scavenius, Carsten, Thybo, Morten, Callesen, Morten M., Kløverpris, Søren, Oxvig, Claus, Enghild, Jan J., Sørensen, Esben S.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242673/