Effect of treadmill exercise on social interaction and tyrosine hydroxylase expression in the attention-deficit/ hyperactivity disorder rats
Attention-deficit/hyperactivity disorder (ADHD) involves clinically heterogeneous dysfunctions of sustained attention, with behavioral hyper-activity and impulsivity. The exact underlying mechanisms of ADHD are not known, however, impairment of dopaminergic system in the nigrostriatal pathway was su...
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Korean Society of Exercise Rehabilitation
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237838/ |
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pubmed-42378382014-11-25 Effect of treadmill exercise on social interaction and tyrosine hydroxylase expression in the attention-deficit/ hyperactivity disorder rats Baek, Dae-Jung Lee, Chae-Bin Baek, Seung-Soo Original Article Attention-deficit/hyperactivity disorder (ADHD) involves clinically heterogeneous dysfunctions of sustained attention, with behavioral hyper-activity and impulsivity. The exact underlying mechanisms of ADHD are not known, however, impairment of dopaminergic system in the nigrostriatal pathway was suggested as the one of the possible mechanisms of ADHD. Tyrosine hydroxylase (TH) is the rate-limiting enzyme that is involved in the synthesis of dopamine. Spontaneous hypertensive rats have been used as the animal model for ADHD. Physical exercise is known to restore the brain functions disrupted by several neurode-generative and psychiatric disorders. In the present study, we investigated whether treadmill exercise exerts therapeutic effect on ADHD. Social interaction test for the evaluation of impulsivity was performed using spontaneous hypertensive rats. TH expressions in the substantia nigra and striatum were evaluated by immunohistochemistry. In the present results, the rats of ADHD model showed hyper-social behaviors. TH expressions in the substantia nigra and striatum were decreased in the rats of ADHD model. Treadmill exercise alleviated hyper-social behaviors in the ADHD rats. TH expressions of ADHD rats were also enhanced by treadmill exercise. Here in this study, we showed that treadmill exercise effectively alleviates the ADHD-induced symptoms through enhancing of TH expression in the brain. Korean Society of Exercise Rehabilitation 2014-10-31 /pmc/articles/PMC4237838/ /pubmed/25426460 http://dx.doi.org/10.12965/jer.140162 Text en Copyright © 2014 Korean Society of Exercise Rehabilitation This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Baek, Dae-Jung Lee, Chae-Bin Baek, Seung-Soo |
| spellingShingle |
Baek, Dae-Jung Lee, Chae-Bin Baek, Seung-Soo Effect of treadmill exercise on social interaction and tyrosine hydroxylase expression in the attention-deficit/ hyperactivity disorder rats |
| author_facet |
Baek, Dae-Jung Lee, Chae-Bin Baek, Seung-Soo |
| author_sort |
Baek, Dae-Jung |
| title |
Effect of treadmill exercise on social interaction and tyrosine hydroxylase expression in the attention-deficit/ hyperactivity disorder rats |
| title_short |
Effect of treadmill exercise on social interaction and tyrosine hydroxylase expression in the attention-deficit/ hyperactivity disorder rats |
| title_full |
Effect of treadmill exercise on social interaction and tyrosine hydroxylase expression in the attention-deficit/ hyperactivity disorder rats |
| title_fullStr |
Effect of treadmill exercise on social interaction and tyrosine hydroxylase expression in the attention-deficit/ hyperactivity disorder rats |
| title_full_unstemmed |
Effect of treadmill exercise on social interaction and tyrosine hydroxylase expression in the attention-deficit/ hyperactivity disorder rats |
| title_sort |
effect of treadmill exercise on social interaction and tyrosine hydroxylase expression in the attention-deficit/ hyperactivity disorder rats |
| description |
Attention-deficit/hyperactivity disorder (ADHD) involves clinically heterogeneous dysfunctions of sustained attention, with behavioral hyper-activity and impulsivity. The exact underlying mechanisms of ADHD are not known, however, impairment of dopaminergic system in the nigrostriatal pathway was suggested as the one of the possible mechanisms of ADHD. Tyrosine hydroxylase (TH) is the rate-limiting enzyme that is involved in the synthesis of dopamine. Spontaneous hypertensive rats have been used as the animal model for ADHD. Physical exercise is known to restore the brain functions disrupted by several neurode-generative and psychiatric disorders. In the present study, we investigated whether treadmill exercise exerts therapeutic effect on ADHD. Social interaction test for the evaluation of impulsivity was performed using spontaneous hypertensive rats. TH expressions in the substantia nigra and striatum were evaluated by immunohistochemistry. In the present results, the rats of ADHD model showed hyper-social behaviors. TH expressions in the substantia nigra and striatum were decreased in the rats of ADHD model. Treadmill exercise alleviated hyper-social behaviors in the ADHD rats. TH expressions of ADHD rats were also enhanced by treadmill exercise. Here in this study, we showed that treadmill exercise effectively alleviates the ADHD-induced symptoms through enhancing of TH expression in the brain. |
| publisher |
Korean Society of Exercise Rehabilitation |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237838/ |
| _version_ |
1613158847844712448 |