Uromodulin Retention in Thick Ascending Limb of Henle's Loop Affects SCD1 in Neighboring Proximal Tubule: Renal Transcriptome Studies in Mouse Models of Uromodulin-Associated Kidney Disease

Uromodulin Retention in Thick Ascending Limb of Henle's Loop Affects SCD1 in Neighboring Proximal Tubule: Renal Transcriptome Studies in Mouse Models of Uromodulin-Associated Kidney Disease

Uromodulin-associated kidney disease (UAKD) is a hereditary progressive renal disease which can lead to renal failure and requires renal replacement therapy. UAKD belongs to the endoplasmic reticulum storage diseases due to maturation defect of mutant uromodulin and its retention in the enlarged end...

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Main Authors: Horsch, Marion, Beckers, Johannes, Fuchs, Helmut, Gailus-Durner, Valérie, Hrabě de Angelis, Martin, Rathkolb, Birgit, Wolf, Eckhard, Aigner, Bernhard, Kemter, Elisabeth
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237372/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237372/

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