Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3

Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3

The centromere-specific histone H3 variant, CENP-A, is overexpressed in particular aggressive cancer cells, where it can be mislocalized ectopically in the form of heterotypic nucleosomes containing H3.3. In the present study, we report the crystal structure of the heterotypic CENP-A/H3.3 particle a...

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Bibliographic Details
Main Authors: Arimura, Yasuhiro, Shirayama, Kazuyoshi, Horikoshi, Naoki, Fujita, Risa, Taguchi, Hiroyuki, Kagawa, Wataru, Fukagawa, Tatsuo, Almouzni, Geneviève, Kurumizaka, Hitoshi
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236741/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236741/

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