TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

Telomeres protect the ends of linear genomes, and the gradual loss of telomeres is associated with cellular ageing. Telomere protection involves the insertion of the 3′ overhang facilitated by telomere repeat-binding factor 2 (TRF2) into telomeric DNA, forming t-loops. We present evidence suggesting...

Full description

Bibliographic Details
Main Authors: Wood, Ashley M., Danielsen, Jannie M. Rendtlew, Lucas, Catherine A., Rice, Ellen L., Scalzo, David, Shimi, Takeshi, Goldman, Robert D., Smith, Erica D., Le Beau, Michelle M., Kosak, Steven T.
Format: Online
Language:English
Published: Nature Pub. Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235626/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235626/

Similar Items