Carbamylation of immunoglobulin abrogates activation of the classical complement pathway

Carbamylation of immunoglobulin abrogates activation of the classical complement pathway

Post-translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory conditions through myeloperoxidase-dependent cyanate (CNO−) formation. We analyzed...

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Bibliographic Details
Main Authors: Koro, Catalin, Bielecka, Ewa, Dahl-Knudsen, Anders, Enghild, Jan J, Scavenius, Carsten, Brun, Johan G, Binder, Veronika, Hellvard, Annelie, Bergum, Brith, Jonsson, Roland, Potempa, Jan, Blom, Anna M, Mydel, Piotr
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232992/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232992/

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