Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system

Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system

The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system (CNS) malfunction has triggered intensive investigation of the biological roles played by DISC1...

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Main Authors: Randall, Andrew D, Kurihara, Mai, Brandon, Nicholas J, Brown, Jon T
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232872/
id pubmed-4232872
recordtype oai_dc
spelling pubmed-42328722014-12-19 Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system Randall, Andrew D Kurihara, Mai Brandon, Nicholas J Brown, Jon T Special Issue: Synaptic Basis of Disease The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system (CNS) malfunction has triggered intensive investigation of the biological roles played by DISC1, with the hope that this may shed new light on the pathobiology of psychiatric disease. Such work has ranged from investigations of animal behavior to detailed molecular-level analysis of the assemblies that DISC1 forms with other proteins. Here, we discuss the evidence for a role of DISC1 in synaptic function in the mammalian CNS. BlackWell Publishing Ltd 2014-04 2014-04-08 /pmc/articles/PMC4232872/ /pubmed/24712987 http://dx.doi.org/10.1111/ejn.12500 Text en Copyright © 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Randall, Andrew D
Kurihara, Mai
Brandon, Nicholas J
Brown, Jon T
spellingShingle Randall, Andrew D
Kurihara, Mai
Brandon, Nicholas J
Brown, Jon T
Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
author_facet Randall, Andrew D
Kurihara, Mai
Brandon, Nicholas J
Brown, Jon T
author_sort Randall, Andrew D
title Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
title_short Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
title_full Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
title_fullStr Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
title_full_unstemmed Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
title_sort disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
description The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system (CNS) malfunction has triggered intensive investigation of the biological roles played by DISC1, with the hope that this may shed new light on the pathobiology of psychiatric disease. Such work has ranged from investigations of animal behavior to detailed molecular-level analysis of the assemblies that DISC1 forms with other proteins. Here, we discuss the evidence for a role of DISC1 in synaptic function in the mammalian CNS.
publisher BlackWell Publishing Ltd
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232872/
_version_ 1613157001746972672

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