Immediate hypersensitivity reaction following liposomal amphotericin-B (AmBisome) infusion

Liposomal amphotericin-B (AmBisome) is now becoming first choice for the treatment of visceral leishmaniasis (kala-azar) patients due to high efficacy and less toxicity. The reported incidence of hypersensitivity reactions to liposomal amphotericin-B (AmBisome), especially during therapy, is very ra...

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Main Authors:	Nath, Proggananda, Basher, Ariful, Harada, Michiyo, Sarkar, Santana, Selim, Shahjada, Maude, Richard J, Noiri, Eisei, Faiz, Abul
Format:	Online
Language:	English
Published:	SAGE Publications 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232346/

id	pubmed-4232346
recordtype	oai_dc
spelling	pubmed-42323462014-11-21 Immediate hypersensitivity reaction following liposomal amphotericin-B (AmBisome) infusion Nath, Proggananda Basher, Ariful Harada, Michiyo Sarkar, Santana Selim, Shahjada Maude, Richard J Noiri, Eisei Faiz, Abul Case Reports Liposomal amphotericin-B (AmBisome) is now becoming first choice for the treatment of visceral leishmaniasis (kala-azar) patients due to high efficacy and less toxicity. The reported incidence of hypersensitivity reactions to liposomal amphotericin-B (AmBisome), especially during therapy, is very rare. We report two patients with kala-azar: one developed breathing difficulties and hypotension followed by shock and the other had facial angioedema with chest tightness during treatment. Both patients were managed with immediate action of injection: adrenaline, diphenhydramine and hydrocortisone. In our experience, AmBisome can cause severe hypersensitivity reactions that warrant proper support and close supervision. SAGE Publications 2014-10 /pmc/articles/PMC4232346/ /pubmed/25139411 http://dx.doi.org/10.1177/0049475514543655 Text en © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Nath, Proggananda Basher, Ariful Harada, Michiyo Sarkar, Santana Selim, Shahjada Maude, Richard J Noiri, Eisei Faiz, Abul
spellingShingle	Nath, Proggananda Basher, Ariful Harada, Michiyo Sarkar, Santana Selim, Shahjada Maude, Richard J Noiri, Eisei Faiz, Abul Immediate hypersensitivity reaction following liposomal amphotericin-B (AmBisome) infusion
author_facet	Nath, Proggananda Basher, Ariful Harada, Michiyo Sarkar, Santana Selim, Shahjada Maude, Richard J Noiri, Eisei Faiz, Abul
author_sort	Nath, Proggananda
title	Immediate hypersensitivity reaction following liposomal amphotericin-B (AmBisome) infusion
title_short	Immediate hypersensitivity reaction following liposomal amphotericin-B (AmBisome) infusion
title_full	Immediate hypersensitivity reaction following liposomal amphotericin-B (AmBisome) infusion
title_fullStr	Immediate hypersensitivity reaction following liposomal amphotericin-B (AmBisome) infusion
title_full_unstemmed	Immediate hypersensitivity reaction following liposomal amphotericin-B (AmBisome) infusion
title_sort	immediate hypersensitivity reaction following liposomal amphotericin-b (ambisome) infusion
description	Liposomal amphotericin-B (AmBisome) is now becoming first choice for the treatment of visceral leishmaniasis (kala-azar) patients due to high efficacy and less toxicity. The reported incidence of hypersensitivity reactions to liposomal amphotericin-B (AmBisome), especially during therapy, is very rare. We report two patients with kala-azar: one developed breathing difficulties and hypotension followed by shock and the other had facial angioedema with chest tightness during treatment. Both patients were managed with immediate action of injection: adrenaline, diphenhydramine and hydrocortisone. In our experience, AmBisome can cause severe hypersensitivity reactions that warrant proper support and close supervision.
publisher	SAGE Publications
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232346/
_version_	1613156755001311232

Immediate hypersensitivity reaction following liposomal amphotericin-B (AmBisome) infusion

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