α-Actinin-4-Mediated FSGS: An Inherited Kidney Disease Caused by an Aggregated and Rapidly Degraded Cytoskeletal Protein

α-Actinin-4-Mediated FSGS: An Inherited Kidney Disease Caused by an Aggregated and Rapidly Degraded Cytoskeletal Protein

Focal segmental glomerulosclerosis (FSGS) is a common pattern of renal injury, seen as both a primary disorder and as a consequence of underlying insults such as diabetes, HIV infection, and hypertension. Point mutations in theα-actinin-4 gene ACTN4 cause an autosomal dominant form of human FSGS. We...

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Bibliographic Details
Main Authors: Yao, June, Le, Tu Cam, Kos, Claudine H, Henderson, Joel M, Allen, Phillip G, Denker, Bradley M, Pollak, Martin R
Format: Online
Language:English
Published: Public Library of Science 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC423141/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC423141/

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