Effects of Nitrate Supplementation on Cardiovascular and Autonomic Reactivity in African-American Females

Effects of Nitrate Supplementation on Cardiovascular and Autonomic Reactivity in African-American Females

Previous studies have shown that beetroot juice (BJ) decreases systolic blood pressure (SBP) and oxygen demand. This study tests the hypothesis that a beetroot juice (BJ) treatment increases heart rate variability (HRV) measured by the average standard deviation of normal-normal electrocardiogram RR...

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Main Authors: Bond, Vernon, Curry, Bryan H., Adams, R. George, Asadi, M. Sadegh, Stancil, Kimani A., Millis, Richard M., Haddad, Georges E.
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229077/
id pubmed-4229077
recordtype oai_dc
spelling pubmed-42290772014-11-12 Effects of Nitrate Supplementation on Cardiovascular and Autonomic Reactivity in African-American Females Bond, Vernon Curry, Bryan H. Adams, R. George Asadi, M. Sadegh Stancil, Kimani A. Millis, Richard M. Haddad, Georges E. Article Previous studies have shown that beetroot juice (BJ) decreases systolic blood pressure (SBP) and oxygen demand. This study tests the hypothesis that a beetroot juice (BJ) treatment increases heart rate variability (HRV) measured by the average standard deviation of normal-normal electrocardiogram RR intervals (SDNN) and the low frequency (LF), mainly sympathetic, fast Fourier transform spectral index of HRV. The subjects were 13 healthy young adult African-American females. Placebo control orange juice (OJ) and BJ treatments were given on separate days. Blood nitric oxide [NO], SBP and RR intervals were measured at rest and at constant workloads set to 40% and 80% of the predetermined VO2peak. Two hours after ingestion the BJ treatment increased [NO] and decreased SBP. BJ also increased SDNN at rest and at the 40% VO2peak workload, without significant effects on LF. SDNN was significantly greater after the BJ than after the OJ treatment, across the two physical activity conditions and SDNN was (negatively) correlated with SBP. These results suggest that BJ decreases SBP and increases HRV at rest and during aerobic exercise. Similar results in subjects with prehypertension or hypertension could translate to a dietary nitrate treatment for hypertension. 2014-02-23 /pmc/articles/PMC4229077/ /pubmed/25401100 http://dx.doi.org/10.1155/2014/676235 Text en Copyright © 2014 Vernon Bond et al. http://creativecommons.org/licenses/by/2.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Bond, Vernon
Curry, Bryan H.
Adams, R. George
Asadi, M. Sadegh
Stancil, Kimani A.
Millis, Richard M.
Haddad, Georges E.
spellingShingle Bond, Vernon
Curry, Bryan H.
Adams, R. George
Asadi, M. Sadegh
Stancil, Kimani A.
Millis, Richard M.
Haddad, Georges E.
Effects of Nitrate Supplementation on Cardiovascular and Autonomic Reactivity in African-American Females
author_facet Bond, Vernon
Curry, Bryan H.
Adams, R. George
Asadi, M. Sadegh
Stancil, Kimani A.
Millis, Richard M.
Haddad, Georges E.
author_sort Bond, Vernon
title Effects of Nitrate Supplementation on Cardiovascular and Autonomic Reactivity in African-American Females
title_short Effects of Nitrate Supplementation on Cardiovascular and Autonomic Reactivity in African-American Females
title_full Effects of Nitrate Supplementation on Cardiovascular and Autonomic Reactivity in African-American Females
title_fullStr Effects of Nitrate Supplementation on Cardiovascular and Autonomic Reactivity in African-American Females
title_full_unstemmed Effects of Nitrate Supplementation on Cardiovascular and Autonomic Reactivity in African-American Females
title_sort effects of nitrate supplementation on cardiovascular and autonomic reactivity in african-american females
description Previous studies have shown that beetroot juice (BJ) decreases systolic blood pressure (SBP) and oxygen demand. This study tests the hypothesis that a beetroot juice (BJ) treatment increases heart rate variability (HRV) measured by the average standard deviation of normal-normal electrocardiogram RR intervals (SDNN) and the low frequency (LF), mainly sympathetic, fast Fourier transform spectral index of HRV. The subjects were 13 healthy young adult African-American females. Placebo control orange juice (OJ) and BJ treatments were given on separate days. Blood nitric oxide [NO], SBP and RR intervals were measured at rest and at constant workloads set to 40% and 80% of the predetermined VO2peak. Two hours after ingestion the BJ treatment increased [NO] and decreased SBP. BJ also increased SDNN at rest and at the 40% VO2peak workload, without significant effects on LF. SDNN was significantly greater after the BJ than after the OJ treatment, across the two physical activity conditions and SDNN was (negatively) correlated with SBP. These results suggest that BJ decreases SBP and increases HRV at rest and during aerobic exercise. Similar results in subjects with prehypertension or hypertension could translate to a dietary nitrate treatment for hypertension.
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229077/
_version_ 1613155584468582400

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