ADAMTS proteoglycanases in the physiological and pathological central nervous system

ADAMTS proteoglycanases in the physiological and pathological central nervous system

ADAMTS-1, -4, -5 and -9 belong to ‘a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)’ family and more precisely to the proteoglycanases subgroup based on their common ability to degrade chondroitin sulfate proteoglycans. They have been extensively investigated for their involve...

Full description

Bibliographic Details
Main Authors: Lemarchant, Sighild, Pruvost, Mathilde, Montaner, Joan, Emery, Evelyne, Vivien, Denis, Kanninen, Katja, Koistinaho, Jari
Format: Online
Language:English
Published: BioMed Central 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228433/
id pubmed-4228433
recordtype oai_dc
spelling pubmed-42284332014-11-13 ADAMTS proteoglycanases in the physiological and pathological central nervous system Lemarchant, Sighild Pruvost, Mathilde Montaner, Joan Emery, Evelyne Vivien, Denis Kanninen, Katja Koistinaho, Jari Review ADAMTS-1, -4, -5 and -9 belong to ‘a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)’ family and more precisely to the proteoglycanases subgroup based on their common ability to degrade chondroitin sulfate proteoglycans. They have been extensively investigated for their involvement in inflammation-induced osteoarthritis, and a growing body of evidence indicates that they may be of key importance in the physiological and pathological central nervous system (CNS). In this review, we discuss the deregulated expression of ADAMTS proteoglycanases during acute CNS injuries, such as stroke and spinal cord injury. Then, we provide new insights on ADAMTS proteoglycanases mediating synaptic plasticity, neurorepair, angiogenesis and inflammation mechanisms. Altogether, this review allows us to propose that ADAMTS proteoglycanases may be original therapeutic targets for CNS injuries. BioMed Central 2013-10-31 /pmc/articles/PMC4228433/ /pubmed/24176075 http://dx.doi.org/10.1186/1742-2094-10-133 Text en Copyright © 2013 Lemarchant et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Lemarchant, Sighild
Pruvost, Mathilde
Montaner, Joan
Emery, Evelyne
Vivien, Denis
Kanninen, Katja
Koistinaho, Jari
spellingShingle Lemarchant, Sighild
Pruvost, Mathilde
Montaner, Joan
Emery, Evelyne
Vivien, Denis
Kanninen, Katja
Koistinaho, Jari
ADAMTS proteoglycanases in the physiological and pathological central nervous system
author_facet Lemarchant, Sighild
Pruvost, Mathilde
Montaner, Joan
Emery, Evelyne
Vivien, Denis
Kanninen, Katja
Koistinaho, Jari
author_sort Lemarchant, Sighild
title ADAMTS proteoglycanases in the physiological and pathological central nervous system
title_short ADAMTS proteoglycanases in the physiological and pathological central nervous system
title_full ADAMTS proteoglycanases in the physiological and pathological central nervous system
title_fullStr ADAMTS proteoglycanases in the physiological and pathological central nervous system
title_full_unstemmed ADAMTS proteoglycanases in the physiological and pathological central nervous system
title_sort adamts proteoglycanases in the physiological and pathological central nervous system
description ADAMTS-1, -4, -5 and -9 belong to ‘a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)’ family and more precisely to the proteoglycanases subgroup based on their common ability to degrade chondroitin sulfate proteoglycans. They have been extensively investigated for their involvement in inflammation-induced osteoarthritis, and a growing body of evidence indicates that they may be of key importance in the physiological and pathological central nervous system (CNS). In this review, we discuss the deregulated expression of ADAMTS proteoglycanases during acute CNS injuries, such as stroke and spinal cord injury. Then, we provide new insights on ADAMTS proteoglycanases mediating synaptic plasticity, neurorepair, angiogenesis and inflammation mechanisms. Altogether, this review allows us to propose that ADAMTS proteoglycanases may be original therapeutic targets for CNS injuries.
publisher BioMed Central
publishDate 2013
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228433/
_version_ 1613155340947292160

Similar Items