Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS), a Chinese medicine fo...

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Main Authors:	Hou, Yujun, Wang, Ying, Zhao, Jian, Li, Xiaohang, Cui, Jin, Ding, Jianqing, Zeng, Xianglu, Ling, Yun, Shen, Xiaoheng, Chen, Shengdi, Huang, Chenggang, Pei, Gang
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227681/

id	pubmed-4227681
recordtype	oai_dc
spelling	pubmed-42276812014-11-18 Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits Hou, Yujun Wang, Ying Zhao, Jian Li, Xiaohang Cui, Jin Ding, Jianqing Wang, Ying Zeng, Xianglu Ling, Yun Shen, Xiaoheng Chen, Shengdi Huang, Chenggang Pei, Gang Research Article Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS), a Chinese medicine formula composed of Rhizoma Acori Tatarinowii (AT), Poria cum Radix Pini (PRP) and Radix Polygalae (RP), is a typical prescription against memory deficits. Here, we assessed the efficacy of SS against AD. Oral administration of SS ameliorated the cognitive impairment of AD transgenic mice, with reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss in the brains of AD mice. Consistently, SS treatment reduced amyloid-related locomotor dysfunctions and premature death of AD transgenic Drosophila. Mechanistic studies showed that RP reduced Aβ generation, whereas AT and PRP exerted neuroprotective effects against Aβ. Taken together, our study indicates that SS could be effective against AD, providing a practical therapeutic strategy against the disease. Public Library of Science 2014-11-11 /pmc/articles/PMC4227681/ /pubmed/25386946 http://dx.doi.org/10.1371/journal.pone.0111215 Text en © 2014 Hou et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hou, Yujun Wang, Ying Zhao, Jian Li, Xiaohang Cui, Jin Ding, Jianqing Wang, Ying Zeng, Xianglu Ling, Yun Shen, Xiaoheng Chen, Shengdi Huang, Chenggang Pei, Gang
spellingShingle	Hou, Yujun Wang, Ying Zhao, Jian Li, Xiaohang Cui, Jin Ding, Jianqing Wang, Ying Zeng, Xianglu Ling, Yun Shen, Xiaoheng Chen, Shengdi Huang, Chenggang Pei, Gang Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits
author_facet	Hou, Yujun Wang, Ying Zhao, Jian Li, Xiaohang Cui, Jin Ding, Jianqing Wang, Ying Zeng, Xianglu Ling, Yun Shen, Xiaoheng Chen, Shengdi Huang, Chenggang Pei, Gang
author_sort	Hou, Yujun
title	Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits
title_short	Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits
title_full	Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits
title_fullStr	Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits
title_full_unstemmed	Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits
title_sort	smart soup, a traditional chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits
description	Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS), a Chinese medicine formula composed of Rhizoma Acori Tatarinowii (AT), Poria cum Radix Pini (PRP) and Radix Polygalae (RP), is a typical prescription against memory deficits. Here, we assessed the efficacy of SS against AD. Oral administration of SS ameliorated the cognitive impairment of AD transgenic mice, with reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss in the brains of AD mice. Consistently, SS treatment reduced amyloid-related locomotor dysfunctions and premature death of AD transgenic Drosophila. Mechanistic studies showed that RP reduced Aβ generation, whereas AT and PRP exerted neuroprotective effects against Aβ. Taken together, our study indicates that SS could be effective against AD, providing a practical therapeutic strategy against the disease.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227681/
_version_	1613155014743687168

Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits

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