Oligodendrocyte Precursor Cells Modulate the Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2

Oligodendrocyte Precursor Cells Modulate the Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2

This study shows that the activity of neurons can trigger shedding of a protein, NG2, from the surface of oligodendrocyte precursor cells; this protein in turn modulates synaptic transmission, revealing a two-way conversation between neurons and glia.

Bibliographic Details
Main Authors: Sakry, Dominik, Neitz, Angela, Singh, Jeet, Frischknecht, Renato, Marongiu, Daniele, Binamé, Fabien, Perera, Sumudhu S., Endres, Kristina, Lutz, Beat, Radyushkin, Konstantin, Trotter, Jacqueline, Mittmann, Thomas
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227637/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227637/

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