Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy
Genomic alterations may make cancer cells more dependent than normal cells on mechanisms of proteostasis, including protein folding and degradation. This proposition is the basis for the clinical use of proteasome inhibitors to treat multiple myeloma and mantle cell lymphoma. However, proteasome inh...
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| Format: | Online |
| Language: | English |
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BioMed Central
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226866/ |