Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment

Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment

Tasquinimod, an orally active quinoline-3-carboxamide, binds with high affinity to HDAC4 and S100A9 in cancer and infiltrating host cells within compromised tumor microenvironment inhibiting adaptive survival pathways needed for an angiogenic response. Clinical trials document that as low as 0.5-1mg...

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Bibliographic Details
Main Authors: Isaacs, John T., Dalrymple, Susan L., Rosen, D. Marc, Hammers, Hans, Olsson, Anders, Leanderson, Tomas
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226669/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226669/

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