Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein–Experimental Autoimmune Encephalomyelitis Mice

Optic chiasm lesions in myelin oligodendrocyte glycoprotein (MOG)–experimental autoimmune encephalomyelitis (EAE) mice were characterized using magnetic resonance imaging (MRI) and validated using electron microscopy (EM). MR images were collected from 3 days after induction to remission, approximat...

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Main Authors:	Herrera, Sheryl L, Palmer, Vanessa L, Whittaker, Heather, Smith, Blair Cardigan, Kim, Annie, Schellenberg, Angela E, Thiessen, Jonathan D, Buist, Richard, Del Bigio, Marc R, Martin, Melanie
Format:	Online
Language:	English
Published:	Libertas Academica 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226389/

id	pubmed-4226389
recordtype	oai_dc
spelling	pubmed-42263892014-12-17 Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein–Experimental Autoimmune Encephalomyelitis Mice Herrera, Sheryl L Palmer, Vanessa L Whittaker, Heather Smith, Blair Cardigan Kim, Annie Schellenberg, Angela E Thiessen, Jonathan D Buist, Richard Del Bigio, Marc R Martin, Melanie Original Research Optic chiasm lesions in myelin oligodendrocyte glycoprotein (MOG)–experimental autoimmune encephalomyelitis (EAE) mice were characterized using magnetic resonance imaging (MRI) and validated using electron microscopy (EM). MR images were collected from 3 days after induction to remission, approximately 20 days after induction. Hematoxylin and eosin, solochrome cyanin–stained sections, and EM images were obtained from the optic chiasms of some mice approximately 4 days after disease onset when their scores were thought to be the highest. T2-weighted imaging and apparent diffusion coefficient map hyperintensities corresponded to abnormalities in the optic chiasms of EAE mice. Mixed inflammation was concentrated at the lateral surface. Degeneration of oligodendrocytes, myelin, and early axonal damage were also apparent. A marked increase in chiasm thickness was observed. T2-weighted and diffusion-weighted MRI can detect abnormalities in the optic chiasms of MOG-EAE mice. MRI is an important method in the study of this model toward understanding optic neuritis. Libertas Academica 2014-11-09 /pmc/articles/PMC4226389/ /pubmed/25520558 http://dx.doi.org/10.4137/MRI.S19750 Text en © 2014 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Herrera, Sheryl L Palmer, Vanessa L Whittaker, Heather Smith, Blair Cardigan Kim, Annie Schellenberg, Angela E Thiessen, Jonathan D Buist, Richard Del Bigio, Marc R Martin, Melanie
spellingShingle	Herrera, Sheryl L Palmer, Vanessa L Whittaker, Heather Smith, Blair Cardigan Kim, Annie Schellenberg, Angela E Thiessen, Jonathan D Buist, Richard Del Bigio, Marc R Martin, Melanie Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein–Experimental Autoimmune Encephalomyelitis Mice
author_facet	Herrera, Sheryl L Palmer, Vanessa L Whittaker, Heather Smith, Blair Cardigan Kim, Annie Schellenberg, Angela E Thiessen, Jonathan D Buist, Richard Del Bigio, Marc R Martin, Melanie
author_sort	Herrera, Sheryl L
title	Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein–Experimental Autoimmune Encephalomyelitis Mice
title_short	Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein–Experimental Autoimmune Encephalomyelitis Mice
title_full	Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein–Experimental Autoimmune Encephalomyelitis Mice
title_fullStr	Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein–Experimental Autoimmune Encephalomyelitis Mice
title_full_unstemmed	Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein–Experimental Autoimmune Encephalomyelitis Mice
title_sort	damage to the optic chiasm in myelin oligodendrocyte glycoprotein–experimental autoimmune encephalomyelitis mice
description	Optic chiasm lesions in myelin oligodendrocyte glycoprotein (MOG)–experimental autoimmune encephalomyelitis (EAE) mice were characterized using magnetic resonance imaging (MRI) and validated using electron microscopy (EM). MR images were collected from 3 days after induction to remission, approximately 20 days after induction. Hematoxylin and eosin, solochrome cyanin–stained sections, and EM images were obtained from the optic chiasms of some mice approximately 4 days after disease onset when their scores were thought to be the highest. T2-weighted imaging and apparent diffusion coefficient map hyperintensities corresponded to abnormalities in the optic chiasms of EAE mice. Mixed inflammation was concentrated at the lateral surface. Degeneration of oligodendrocytes, myelin, and early axonal damage were also apparent. A marked increase in chiasm thickness was observed. T2-weighted and diffusion-weighted MRI can detect abnormalities in the optic chiasms of MOG-EAE mice. MRI is an important method in the study of this model toward understanding optic neuritis.
publisher	Libertas Academica
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226389/
_version_	1613154445009354752

Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein–Experimental Autoimmune Encephalomyelitis Mice

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