Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection

Inflammation is observed in Alzheimer’s disease (AD) subject brains. Inflammation-relevant genes are increasingly implicated in AD genetic studies, and inflammatory cytokines to some extent even function as peripheral biomarkers. What underlies AD inflammation is unclear, but no “foreign” agent has...

Full description

Bibliographic Details
Main Authors:	Wilkins, Heather M., Carl, Steven M., Greenlief, Alison C. S., Festoff, Barry W., Swerdlow, Russell H.
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226164/

id	pubmed-4226164
recordtype	oai_dc
spelling	pubmed-42261642014-11-25 Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection Wilkins, Heather M. Carl, Steven M. Greenlief, Alison C. S. Festoff, Barry W. Swerdlow, Russell H. Neuroscience Inflammation is observed in Alzheimer’s disease (AD) subject brains. Inflammation-relevant genes are increasingly implicated in AD genetic studies, and inflammatory cytokines to some extent even function as peripheral biomarkers. What underlies AD inflammation is unclear, but no “foreign” agent has been implicated. This suggests that internally produced damage-associated molecular pattern (DAMPs) molecules may drive inflammation in AD. A more complete characterization and understanding of AD-relevant DAMPs could advance our understanding of AD and suggest novel therapeutic strategies. In this review, we consider the possibility that mitochondria, intracellular organelles that resemble bacteria in many ways, trigger and maintain chronic inflammation in AD subjects. Data supporting the possible nexus between AD-associated bioenergetic dysfunction are discussed. Frontiers Media S.A. 2014-11-10 /pmc/articles/PMC4226164/ /pubmed/25426068 http://dx.doi.org/10.3389/fnagi.2014.00311 Text en Copyright © 2014 Wilkins, Carl, Greenlief, Festoff and Swerdlow. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wilkins, Heather M. Carl, Steven M. Greenlief, Alison C. S. Festoff, Barry W. Swerdlow, Russell H.
spellingShingle	Wilkins, Heather M. Carl, Steven M. Greenlief, Alison C. S. Festoff, Barry W. Swerdlow, Russell H. Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection
author_facet	Wilkins, Heather M. Carl, Steven M. Greenlief, Alison C. S. Festoff, Barry W. Swerdlow, Russell H.
author_sort	Wilkins, Heather M.
title	Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection
title_short	Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection
title_full	Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection
title_fullStr	Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection
title_full_unstemmed	Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection
title_sort	bioenergetic dysfunction and inflammation in alzheimer’s disease: a possible connection
description	Inflammation is observed in Alzheimer’s disease (AD) subject brains. Inflammation-relevant genes are increasingly implicated in AD genetic studies, and inflammatory cytokines to some extent even function as peripheral biomarkers. What underlies AD inflammation is unclear, but no “foreign” agent has been implicated. This suggests that internally produced damage-associated molecular pattern (DAMPs) molecules may drive inflammation in AD. A more complete characterization and understanding of AD-relevant DAMPs could advance our understanding of AD and suggest novel therapeutic strategies. In this review, we consider the possibility that mitochondria, intracellular organelles that resemble bacteria in many ways, trigger and maintain chronic inflammation in AD subjects. Data supporting the possible nexus between AD-associated bioenergetic dysfunction are discussed.
publisher	Frontiers Media S.A.
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226164/
_version_	1613154377917267968

Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection

Similar Items