Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease

Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a common feature of numerous aging-related neurodegenerative diseases including Alzheimer’s disease (AD). However, the molecular mechanisms mediating tau truncation and aggregation during aging remain elusive. Her...

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Bibliographic Details
Main Authors: Zhang, Zhentao, Song, Mingke, Liu, Xia, Kang, Seong Su, Kwon, Il-Sun, Duong, Duc M., Seyfried, Nicholas T., Hu, William T., Liu, Zhixue, Wang, Jian-zhi, Cheng, Liming, Sun, Yi E., Yu, Shan Ping, Levey, Allan I., Ye, Keqiang
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224595/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224595/

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