In Silico Prediction of Synthetic Lethality by Meta-Analysis of Genetic Interactions, Functions, and Pathways in Yeast and Human Cancer
A major goal in cancer medicine is to find selective drugs with reduced side effect. A pair of genes is called synthetic lethality (SL) if mutations of both genes will kill a cell while mutation of either gene alone will not. Hence, a gene in SL interactions with a cancer-specific mutated gene will...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Libertas Academica
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224103/ |