48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination

Myelin water imaging provides a novel strategy to assess myelin integrity and corresponding clinical relationships in psychosis, of particular relevance in frontal white matter regions. In the current study, T2 myelin water imaging was used to assess the myelin water fraction (MWF) signal from front...

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Main Authors:	Lang, Donna J.M., Yip, Eugene, MacKay, Alexander L., Thornton, Allen E., Vila-Rodriguez, Fidel, MacEwan, G. William, Kopala, Lili C., Smith, Geoffrey N., Laule, Cornelia, MacRae, Cassie B., Honer, William G.
Format:	Online
Language:	English
Published:	Elsevier 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218939/

id	pubmed-4218939
recordtype	oai_dc
spelling	pubmed-42189392014-11-06 48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination Lang, Donna J.M. Yip, Eugene MacKay, Alexander L. Thornton, Allen E. Vila-Rodriguez, Fidel MacEwan, G. William Kopala, Lili C. Smith, Geoffrey N. Laule, Cornelia MacRae, Cassie B. Honer, William G. Article Myelin water imaging provides a novel strategy to assess myelin integrity and corresponding clinical relationships in psychosis, of particular relevance in frontal white matter regions. In the current study, T2 myelin water imaging was used to assess the myelin water fraction (MWF) signal from frontal areas in a sample of 58 individuals experiencing first-episode psychosis (FEP) and 44 healthy volunteers. No differences in frontal MWF were observed between FEP subjects and healthy volunteers; however, differences in normal patterns of associations between frontal MWF and age, education and IQ were seen. Significant positive relationships between frontal MWF and age, North American Adult Reading Test (NAART) IQ, and years of completed education were observed in healthy volunteers. In contrast, only the relationship between frontal MWF and NAART IQ was significant after Bonferroni correction in the FEP group. Additionally, significant positive relationships between age and MWF in the anterior and posterior internal capsules, the genu, and the splenium were observed in healthy volunteers. In FEP subjects, only the relationship between age and MWF in the splenium was statistically significant. Frontal MWF was not associated with local white matter volume. Altered patterns of association between age, years of education, and MWF in FEP suggest that subtle disturbances in myelination may be present early in the course of psychosis. Elsevier 2014-10-15 /pmc/articles/PMC4218939/ /pubmed/25379454 http://dx.doi.org/10.1016/j.nicl.2014.10.006 Text en © 2014 The Authors. Published by Elsevier Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lang, Donna J.M. Yip, Eugene MacKay, Alexander L. Thornton, Allen E. Vila-Rodriguez, Fidel MacEwan, G. William Kopala, Lili C. Smith, Geoffrey N. Laule, Cornelia MacRae, Cassie B. Honer, William G.
spellingShingle	Lang, Donna J.M. Yip, Eugene MacKay, Alexander L. Thornton, Allen E. Vila-Rodriguez, Fidel MacEwan, G. William Kopala, Lili C. Smith, Geoffrey N. Laule, Cornelia MacRae, Cassie B. Honer, William G. 48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination
author_facet	Lang, Donna J.M. Yip, Eugene MacKay, Alexander L. Thornton, Allen E. Vila-Rodriguez, Fidel MacEwan, G. William Kopala, Lili C. Smith, Geoffrey N. Laule, Cornelia MacRae, Cassie B. Honer, William G.
author_sort	Lang, Donna J.M.
title	48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination
title_short	48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination
title_full	48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination
title_fullStr	48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination
title_full_unstemmed	48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination
title_sort	48 echo t2 myelin imaging of white matter in first-episode schizophrenia: evidence for aberrant myelination
description	Myelin water imaging provides a novel strategy to assess myelin integrity and corresponding clinical relationships in psychosis, of particular relevance in frontal white matter regions. In the current study, T2 myelin water imaging was used to assess the myelin water fraction (MWF) signal from frontal areas in a sample of 58 individuals experiencing first-episode psychosis (FEP) and 44 healthy volunteers. No differences in frontal MWF were observed between FEP subjects and healthy volunteers; however, differences in normal patterns of associations between frontal MWF and age, education and IQ were seen. Significant positive relationships between frontal MWF and age, North American Adult Reading Test (NAART) IQ, and years of completed education were observed in healthy volunteers. In contrast, only the relationship between frontal MWF and NAART IQ was significant after Bonferroni correction in the FEP group. Additionally, significant positive relationships between age and MWF in the anterior and posterior internal capsules, the genu, and the splenium were observed in healthy volunteers. In FEP subjects, only the relationship between age and MWF in the splenium was statistically significant. Frontal MWF was not associated with local white matter volume. Altered patterns of association between age, years of education, and MWF in FEP suggest that subtle disturbances in myelination may be present early in the course of psychosis.
publisher	Elsevier
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218939/
_version_	1613151769720782848

48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination

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