2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins
Coumarins are natural plant products that have been the subject of extensive phytochemical and pharmacological research studies in the past few decades. The core structure of coumarins is derived from the respective cinnamates via ortho-hydroxylation of the aromatic ring, trans/cis isomerization, an...
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| Format: | Online |
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Frontiers Media S.A.
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217350/ |
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pubmed-42173502014-11-17 2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins Shimizu, Bun-Ichi Plant Science Coumarins are natural plant products that have been the subject of extensive phytochemical and pharmacological research studies in the past few decades. The core structure of coumarins is derived from the respective cinnamates via ortho-hydroxylation of the aromatic ring, trans/cis isomerization, and lactonization. Various substitution patterns of coumarins have been reported, whereas the biosynthesis of coumarins remains elusive. Ortho-hydroxylation is a key step in simple coumarin biosynthesis as a branch point from the lignin biosynthetic pathway. 2-Oxoglutarate-dependent dioxygenases (2OGDs) from plants convert cinnamate derivatives into simple coumarins through the process of ortho-hydroxylation. This review describes the 2OGDs involved in coumarin biosynthesis and their substrate specificities. Frontiers Media S.A. 2014-11-03 /pmc/articles/PMC4217350/ /pubmed/25404933 http://dx.doi.org/10.3389/fpls.2014.00549 Text en Copyright © 2014 Shimizu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Shimizu, Bun-Ichi |
| spellingShingle |
Shimizu, Bun-Ichi 2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins |
| author_facet |
Shimizu, Bun-Ichi |
| author_sort |
Shimizu, Bun-Ichi |
| title |
2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins |
| title_short |
2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins |
| title_full |
2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins |
| title_fullStr |
2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins |
| title_full_unstemmed |
2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins |
| title_sort |
2-oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins |
| description |
Coumarins are natural plant products that have been the subject of extensive phytochemical and pharmacological research studies in the past few decades. The core structure of coumarins is derived from the respective cinnamates via ortho-hydroxylation of the aromatic ring, trans/cis isomerization, and lactonization. Various substitution patterns of coumarins have been reported, whereas the biosynthesis of coumarins remains elusive. Ortho-hydroxylation is a key step in simple coumarin biosynthesis as a branch point from the lignin biosynthetic pathway. 2-Oxoglutarate-dependent dioxygenases (2OGDs) from plants convert cinnamate derivatives into simple coumarins through the process of ortho-hydroxylation. This review describes the 2OGDs involved in coumarin biosynthesis and their substrate specificities. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217350/ |
| _version_ |
1613151489865285632 |