Intratubular Spermatocytic Seminomas in 2 Sprague-Dawley Rats
This report describes 2 cases of spontaneous intratubular spermatocytic seminomas in Sprague-Dawley rats. These rats were sacrificed at 10 weeks old (case 1) and 40 weeks old (case 2), respectively. Macroscopically, there were no remarkable changes in either case. Microscopically, tumor cells were...
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| Format: | Online |
| Language: | English |
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Japanese Society of Toxicologic Pathology
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217232/ |
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pubmed-4217232 |
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pubmed-42172322014-11-06 Intratubular Spermatocytic Seminomas in 2 Sprague-Dawley Rats Ishigami, Noriaki Shimouchi, Koji Case Report This report describes 2 cases of spontaneous intratubular spermatocytic seminomas in Sprague-Dawley rats. These rats were sacrificed at 10 weeks old (case 1) and 40 weeks old (case 2), respectively. Macroscopically, there were no remarkable changes in either case. Microscopically, tumor cells were observed within a single seminiferous tubule (case 1) or several seminiferous tubules (case 2). The proliferating tumor cells were a tripartite cell population comprising small lymphocyte-like, intermediate-sized or large-sized cells, with frequent mitoses, arranged in sheets or forming a basal layer around a tubule or tubules. Immunohistochemically, the tumor cells were strongly positive for proliferating cell nuclear antigen and weakly positive for c-kit, neuron specific enolase and VASA. Our cases provide valuable background control information for the occurrence of seminoma in rats. Japanese Society of Toxicologic Pathology 2014-06-09 2014-10 /pmc/articles/PMC4217232/ /pubmed/25378806 http://dx.doi.org/10.1293/tox.2014-0005 Text en ©2014 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Ishigami, Noriaki Shimouchi, Koji |
| spellingShingle |
Ishigami, Noriaki Shimouchi, Koji Intratubular Spermatocytic Seminomas in 2 Sprague-Dawley Rats |
| author_facet |
Ishigami, Noriaki Shimouchi, Koji |
| author_sort |
Ishigami, Noriaki |
| title |
Intratubular Spermatocytic Seminomas in 2 Sprague-Dawley Rats |
| title_short |
Intratubular Spermatocytic Seminomas in 2 Sprague-Dawley Rats |
| title_full |
Intratubular Spermatocytic Seminomas in 2 Sprague-Dawley Rats |
| title_fullStr |
Intratubular Spermatocytic Seminomas in 2 Sprague-Dawley Rats |
| title_full_unstemmed |
Intratubular Spermatocytic Seminomas in 2 Sprague-Dawley Rats |
| title_sort |
intratubular spermatocytic seminomas in 2 sprague-dawley rats |
| description |
This report describes 2 cases of spontaneous intratubular spermatocytic seminomas in Sprague-Dawley rats. These rats were sacrificed at 10 weeks old (case 1) and 40 weeks old (case 2), respectively. Macroscopically, there were no remarkable changes in either case. Microscopically, tumor cells were observed within a single seminiferous tubule (case 1) or several seminiferous tubules (case 2). The proliferating tumor cells were a tripartite cell population comprising small lymphocyte-like, intermediate-sized or large-sized cells, with frequent mitoses, arranged in sheets or forming a basal layer around a tubule or tubules. Immunohistochemically, the tumor cells were strongly positive for proliferating cell nuclear antigen and weakly positive for c-kit, neuron specific enolase and VASA. Our cases provide valuable background control information for the occurrence of seminoma in rats. |
| publisher |
Japanese Society of Toxicologic Pathology |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217232/ |
| _version_ |
1613151441581506560 |