Mechanism of error-free and semi-targeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4
The aromatic amine carcinogen 2-aminofluorene (AF) forms covalent adducts with DNA, predominantly with guanine at the C8 position. Such lesions are bypassed by Y-family polymerases such as Dpo4 via error-free and error-prone mechanisms. We show that Dpo4 catalyzes elongation from a correct 3′-termin...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215948/ |