Cutaneous Epithelial Tumors Induced by Vemurafenib Involve the MAPK and Pi3KCA Pathways but Not HPV nor HPyV Viral Infection

Cutaneous Epithelial Tumors Induced by Vemurafenib Involve the MAPK and Pi3KCA Pathways but Not HPV nor HPyV Viral Infection

The inhibitors of mutant BRAF that are used to treat metastatic melanoma induce squamoproliferative lesions. We conducted a prospective histopathological and molecular study on 27 skin lesions from 12 patients treated with vemurafenib. Mutation hot spots in HRAS, NRAS, KRAS, BRAF, and Pi3KCA were sc...

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Bibliographic Details
Main Authors: Frouin, Eric, Guillot, Bernard, Larrieux, Marion, Tempier, Ariane, Boulle, Nathalie, Foulongne, Vincent, Girard, Céline, Costes, Valérie, Solassol, Jérome
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215900/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215900/

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