Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway

Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway

Multiple myeloma (MM) is a clonal plasma cell disorder affecting the immune system with various systemic symptoms. MM remains incurable even with high dose chemotherapy using conventional drugs, thus necessitating development of novel therapeutic strategies. Gossypol (Gos) is a natural polyphenolic...

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Bibliographic Details
Main Authors: SADAHIRA, KEN, SAGAWA, MORIHIKO, NAKAZATO, TOMONORI, UCHIDA, HIDEO, IKEDA, YASUO, OKAMOTO, SHINICHIRO, NAKAJIMA, HIDEAKI, KIZAKI, MASAHIRO
Format: Online
Language:English
Published: D.A. Spandidos 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215583/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215583/

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