Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts

•The transcription factors STAT2 and IRF9 from Atlantic salmon have been identified.•STAT2 co-expressed with STAT1 translocates to the nucleus upon IFN stimulation.•STAT2 are tyrosine phosphorylated upon type I IFN and IFNγ stimulation.•STAT2 and STAT1, as well as IRF9, activates GAS elements upon I...

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Main Authors:	Sobhkhez, Mehrdad, Skjesol, Astrid, Thomassen, Ernst, Tollersrud, Linn Greiner, Iliev, Dimitar B., Sun, Baojian, Robertsen, Børre, Jørgensen, Jorunn B.
Format:	Online
Language:	English
Published:	Elsevier 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215117/

id	pubmed-4215117
recordtype	oai_dc
spelling	pubmed-42151172014-11-06 Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts Sobhkhez, Mehrdad Skjesol, Astrid Thomassen, Ernst Tollersrud, Linn Greiner Iliev, Dimitar B. Sun, Baojian Robertsen, Børre Jørgensen, Jorunn B. Article •The transcription factors STAT2 and IRF9 from Atlantic salmon have been identified.•STAT2 co-expressed with STAT1 translocates to the nucleus upon IFN stimulation.•STAT2 are tyrosine phosphorylated upon type I IFN and IFNγ stimulation.•STAT2 and STAT1, as well as IRF9, activates GAS elements upon IFNγ stimulation.•Our results suggest novel roles of salmon STAT2 and IRF9 in IFNγ-mediated signaling. Elsevier 2014-10-07 /pmc/articles/PMC4215117/ /pubmed/25379383 http://dx.doi.org/10.1016/j.fob.2014.09.007 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Sobhkhez, Mehrdad Skjesol, Astrid Thomassen, Ernst Tollersrud, Linn Greiner Iliev, Dimitar B. Sun, Baojian Robertsen, Børre Jørgensen, Jorunn B.
spellingShingle	Sobhkhez, Mehrdad Skjesol, Astrid Thomassen, Ernst Tollersrud, Linn Greiner Iliev, Dimitar B. Sun, Baojian Robertsen, Børre Jørgensen, Jorunn B. Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
author_facet	Sobhkhez, Mehrdad Skjesol, Astrid Thomassen, Ernst Tollersrud, Linn Greiner Iliev, Dimitar B. Sun, Baojian Robertsen, Børre Jørgensen, Jorunn B.
author_sort	Sobhkhez, Mehrdad
title	Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
title_short	Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
title_full	Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
title_fullStr	Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
title_full_unstemmed	Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts
title_sort	structural and functional characterization of salmon stat1, stat2 and irf9 homologs sheds light on interferon signaling in teleosts
description	•The transcription factors STAT2 and IRF9 from Atlantic salmon have been identified.•STAT2 co-expressed with STAT1 translocates to the nucleus upon IFN stimulation.•STAT2 are tyrosine phosphorylated upon type I IFN and IFNγ stimulation.•STAT2 and STAT1, as well as IRF9, activates GAS elements upon IFNγ stimulation.•Our results suggest novel roles of salmon STAT2 and IRF9 in IFNγ-mediated signaling.
publisher	Elsevier
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215117/
_version_	1613150681321963520

Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts

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