Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies

Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies

Standard statistical approaches for prioritization of variants for functional testing in fine-mapping studies either use marginal association statistics or estimate posterior probabilities for variants to be causal under simplifying assumptions. Here, we present a probabilistic framework that integr...

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Bibliographic Details
Main Authors: Kichaev, Gleb, Yang, Wen-Yun, Lindstrom, Sara, Hormozdiari, Farhad, Eskin, Eleazar, Price, Alkes L., Kraft, Peter, Pasaniuc, Bogdan
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214605/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214605/

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