Influence of association state and DNA binding on the O2-reactivity of [4Fe-4S] fumarate and nitrate reduction (FNR) regulator

The fumarate and nitrate reduction (FNR) regulator is the master switch for the transition between anaerobic and aerobic respiration in Escherichia coli. Reaction of dimeric [4Fe-4S] FNR with O2 results in conversion of the cluster into a [2Fe-2S] form, via a [3Fe-4S] intermediate, leading to the lo...

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Bibliographic Details
Main Authors: Crack, Jason C., Stapleton, Melanie R., Green, Jeffrey, Thomson, Andrew J., Le Brun, Nick E.
Format: Online
Language:English
Published: Portland Press Ltd. 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214427/