Evolutionarily Conserved Coupling of Adaptive and Excitable Networks Mediates Eukaryotic Chemotaxis

Numerous models explain how cells sense and migrate toward shallow chemoattractant gradients. Studies show that an excitable signal transduction network acts as a pacemaker that controls the cytoskeleton to drive motility. Here we show that this network is required to link stimuli to actin polymeriz...

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Bibliographic Details
Main Authors: Tang, Ming, Wang, Mingjie, Shi, Changji, Iglesias, Pablo A., Devreotes, Peter N., Huang, Chuan-Hsiang
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211273/