Activation of diverse signaling pathways by oncogenic PIK3CA mutations

Activation of diverse signaling pathways by oncogenic PIK3CA mutations

The PIK3CA gene is frequently mutated in human cancers. Here we carry out a SILAC-based quantitative phosphoproteomic analysis using isogenic knockin cell lines containing ‘driver’ oncogenic mutations of PIK3CA to dissect the signaling mechanisms responsible for oncogenic phenotypes induced by mutan...

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Main Authors: Wu, Xinyan, Renuse, Santosh, Sahasrabuddhe, Nandini A., Zahari, Muhammad Saddiq, Chaerkady, Raghothama, Kim, Min-Sik, Nirujogi, Raja S., Mohseni, Morassa, Kumar, Praveen, Raju, Rajesh, Zhong, Jun, Yang, Jian, Neiswinger, Johnathan, Jeong, Jun-Seop, Newman, Robert, Powers, Maureen A., Somani, Babu Lal, Gabrielson, Edward, Sukumar, Saraswati, Stearns, Vered, Qian, Jiang, Zhu, Heng, Vogelstein, Bert, Park, Ben Ho, Pandey, Akhilesh
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210192/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210192/

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