Biophysically Inspired Rational Design of Structured Chimeric Substrates for DNAzyme Cascade Engineering

The development of large-scale molecular computational networks is a promising approach to implementing logical decision making at the nanoscale, analogous to cellular signaling and regulatory cascades. DNA strands with catalytic activity (DNAzymes) are one means of systematically constructing molec...

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Bibliographic Details
Main Authors: Lakin, Matthew R., Brown, Carl W., Horwitz, Eli K., Fanning, M. Leigh, West, Hannah E., Stefanovic, Darko, Graves, Steven W.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210168/