Losartan-induced Ischemic Hepatocellular Hepatotoxicity: A Case Report and Literature Review

With the increasing use of various medications and supplements nowadays, the incidence of abnormal liver function tests and frank hepatic injury is has been increasing. Medications are now considered one of the most common causes of acute hepatic failure in the United States. Losartan was the first...

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Main Authors:	Al-Halawani, Moh’d Z., Thawabi, Mohammad, Asslo, Fady, Shaaban, Hamid, Shamoon, Fayez, Baddoura, Walid J.
Format:	Online
Language:	English
Published:	Medknow Publications & Media Pvt Ltd 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209687/

id	pubmed-4209687
recordtype	oai_dc
spelling	pubmed-42096872014-11-05 Losartan-induced Ischemic Hepatocellular Hepatotoxicity: A Case Report and Literature Review Al-Halawani, Moh’d Z. Thawabi, Mohammad Asslo, Fady Shaaban, Hamid Shamoon, Fayez Baddoura, Walid J. Case Report With the increasing use of various medications and supplements nowadays, the incidence of abnormal liver function tests and frank hepatic injury is has been increasing. Medications are now considered one of the most common causes of acute hepatic failure in the United States. Losartan was the first angiotensin 1 (AT1) receptor blocker approved by FDA for the treatment of arterial hypertension. It is a well-tolerated medication with few significant adverse effects. However, losartan-related hepatotoxicity has been reported rarely. We report a case of acute hepatic injury in an adult patient treated with losartan as a monotherapy for arterial hypertension. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4209687/ /pubmed/25374869 http://dx.doi.org/10.4103/2249-4863.141635 Text en Copyright: © Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Al-Halawani, Moh’d Z. Thawabi, Mohammad Asslo, Fady Shaaban, Hamid Shamoon, Fayez Baddoura, Walid J.
spellingShingle	Al-Halawani, Moh’d Z. Thawabi, Mohammad Asslo, Fady Shaaban, Hamid Shamoon, Fayez Baddoura, Walid J. Losartan-induced Ischemic Hepatocellular Hepatotoxicity: A Case Report and Literature Review
author_facet	Al-Halawani, Moh’d Z. Thawabi, Mohammad Asslo, Fady Shaaban, Hamid Shamoon, Fayez Baddoura, Walid J.
author_sort	Al-Halawani, Moh’d Z.
title	Losartan-induced Ischemic Hepatocellular Hepatotoxicity: A Case Report and Literature Review
title_short	Losartan-induced Ischemic Hepatocellular Hepatotoxicity: A Case Report and Literature Review
title_full	Losartan-induced Ischemic Hepatocellular Hepatotoxicity: A Case Report and Literature Review
title_fullStr	Losartan-induced Ischemic Hepatocellular Hepatotoxicity: A Case Report and Literature Review
title_full_unstemmed	Losartan-induced Ischemic Hepatocellular Hepatotoxicity: A Case Report and Literature Review
title_sort	losartan-induced ischemic hepatocellular hepatotoxicity: a case report and literature review
description	With the increasing use of various medications and supplements nowadays, the incidence of abnormal liver function tests and frank hepatic injury is has been increasing. Medications are now considered one of the most common causes of acute hepatic failure in the United States. Losartan was the first angiotensin 1 (AT1) receptor blocker approved by FDA for the treatment of arterial hypertension. It is a well-tolerated medication with few significant adverse effects. However, losartan-related hepatotoxicity has been reported rarely. We report a case of acute hepatic injury in an adult patient treated with losartan as a monotherapy for arterial hypertension.
publisher	Medknow Publications & Media Pvt Ltd
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209687/
_version_	1613148835198009344

Losartan-induced Ischemic Hepatocellular Hepatotoxicity: A Case Report and Literature Review

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