Impact of Temporal Variation on Design and Analysis of Mouse Knockout Phenotyping Studies

A significant challenge facing high-throughput phenotyping of in-vivo knockout mice is ensuring phenotype calls are robust and reliable. Central to this problem is selecting an appropriate statistical analysis that models both the experimental design (the workflow and the way control mice are select...

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Bibliographic Details
Main Authors: Karp, Natasha A., Speak, Anneliese O., White, Jacqueline K., Adams, David J., Hrabé de Angelis, Martin, Hérault, Yann, Mott, Richard F.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208881/