DDX3X Induces Primary EGFR-TKI Resistance Based on Intratumor Heterogeneity in Lung Cancer Cells Harboring EGFR-Activating Mutations

DDX3X Induces Primary EGFR-TKI Resistance Based on Intratumor Heterogeneity in Lung Cancer Cells Harboring EGFR-Activating Mutations

The specific mechanisms how lung cancer cells harboring epidermal growth factor receptor (EGFR) activating mutations can survive treatment with EGFR-tyrosine kinase inhibitors (TKIs) until they eventually acquire treatment-resistance genetic mutations are unclear. The phenotypic diversity of cancer...

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Bibliographic Details
Main Authors: Nozaki, Koichiro, Kagamu, Hiroshi, Shoji, Satoshi, Igarashi, Natsue, Ohtsubo, Aya, Okajima, Masaaki, Miura, Satoru, Watanabe, Satoshi, Yoshizawa, Hirohisa, Narita, Ichiei
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208809/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208809/

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