Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics

The ability to examine all chromatids from a single meiosis in yeast tetrads has been indispensable for defining mechanisms of homologous recombination initiated by DNA double-strand breaks (DSBs). Using a broadly applicable strategy for the analysis of chromatids from a single meiosis at two recomb...

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Bibliographic Details
Main Authors: Cole, Francesca, Baudat, Frédéric, Grey, Corinne, Keeney, Scott, de Massy, Bernard, Jasin, Maria
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207963/