Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics

Sphingosine 1-phosphate (S1P) is a bioactive lipid that is formed by the phosphorylation of sphingosine and catalysed by sphingosine kinase 1 (SK1) or sphingosine kinase 2 (SK2). Sphingosine kinases play a fundamental role in many signaling pathways associated with cancer, suggesting that proteins b...

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Bibliographic Details
Main Authors: Evangelisti, Cecilia, Evangelisti, Camilla, Teti, Gabriella, Chiarini, Francesca, Falconi, Mirella, Melchionda, Fraia, Pession, Andrea, Bertaina, Alice, Locatelli, Franco, McCubrey, James A., Beak, Dong Jae, Bittman, Robert, Pyne, Susan, Pyne, Nigel J., Martelli, Alberto M.
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202168/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202168/

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