The critical roles of COUP-TFII in tumor progression and metastasis

The critical roles of COUP-TFII in tumor progression and metastasis

Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) belongs to the steroid/thyroid hormone receptor superfamily. Extensive evidence has indicated that COUP-TFII plays a critical and indispensable role in cell-fate specification, organogenesis, angiogenesis, and metabolism as well...

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Main Authors: Qin, Jun, Tsai, Sophia Y, Tsai, Ming-Jer
Format: Online
Language:English
Published: BioMed Central 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201699/
id pubmed-4201699
recordtype oai_dc
spelling pubmed-42016992014-10-19 The critical roles of COUP-TFII in tumor progression and metastasis Qin, Jun Tsai, Sophia Y Tsai, Ming-Jer Review Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) belongs to the steroid/thyroid hormone receptor superfamily. Extensive evidence has indicated that COUP-TFII plays a critical and indispensable role in cell-fate specification, organogenesis, angiogenesis, and metabolism as well as in a variety of diseases. Recent studies obtained from genetically engineered mouse models (GEM) and patient specimen analysis indicate that COUP-TFII is also important for tumor progression and metastasis. In this article, we will comprehensively review the oncogenic roles of COUP-TFII within the tumor microenvironment and tumor cells and delineate the mechanism by which COUP-TFII contributes to tumorigenesis. The applicability of current data to our understanding of the role of COUP-TFII in cancer and the potential therapeutic implications will also be discussed. BioMed Central 2014-10-01 /pmc/articles/PMC4201699/ /pubmed/25328664 http://dx.doi.org/10.1186/2045-3701-4-58 Text en © Qin et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Qin, Jun
Tsai, Sophia Y
Tsai, Ming-Jer
spellingShingle Qin, Jun
Tsai, Sophia Y
Tsai, Ming-Jer
The critical roles of COUP-TFII in tumor progression and metastasis
author_facet Qin, Jun
Tsai, Sophia Y
Tsai, Ming-Jer
author_sort Qin, Jun
title The critical roles of COUP-TFII in tumor progression and metastasis
title_short The critical roles of COUP-TFII in tumor progression and metastasis
title_full The critical roles of COUP-TFII in tumor progression and metastasis
title_fullStr The critical roles of COUP-TFII in tumor progression and metastasis
title_full_unstemmed The critical roles of COUP-TFII in tumor progression and metastasis
title_sort critical roles of coup-tfii in tumor progression and metastasis
description Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) belongs to the steroid/thyroid hormone receptor superfamily. Extensive evidence has indicated that COUP-TFII plays a critical and indispensable role in cell-fate specification, organogenesis, angiogenesis, and metabolism as well as in a variety of diseases. Recent studies obtained from genetically engineered mouse models (GEM) and patient specimen analysis indicate that COUP-TFII is also important for tumor progression and metastasis. In this article, we will comprehensively review the oncogenic roles of COUP-TFII within the tumor microenvironment and tumor cells and delineate the mechanism by which COUP-TFII contributes to tumorigenesis. The applicability of current data to our understanding of the role of COUP-TFII in cancer and the potential therapeutic implications will also be discussed.
publisher BioMed Central
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201699/
_version_ 1613146294151282688

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