Antibacterial activity and cytotoxicity of multi-walled carbon nanotubes decorated with silver nanoparticles

Recently, various nanoscale materials, including silver (Ag) nanoparticles, have been actively studied for their capacity to effectively prevent bacterial growth. A critical challenge is to enhance the antibacterial properties of nanomaterials while maintaining their biocompatibility. The conjugatio...

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Main Authors:	Seo, Youngmin, Hwang, Jangsun, Kim, Jieun, Jeong, Yoon, Hwang, Mintai P, Choi, Jonghoon
Format:	Online
Language:	English
Published:	Dove Medical Press 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200021/

id	pubmed-4200021
recordtype	oai_dc
spelling	pubmed-42000212014-10-21 Antibacterial activity and cytotoxicity of multi-walled carbon nanotubes decorated with silver nanoparticles Seo, Youngmin Hwang, Jangsun Kim, Jieun Jeong, Yoon Hwang, Mintai P Choi, Jonghoon Original Research Recently, various nanoscale materials, including silver (Ag) nanoparticles, have been actively studied for their capacity to effectively prevent bacterial growth. A critical challenge is to enhance the antibacterial properties of nanomaterials while maintaining their biocompatibility. The conjugation of multiple nanomaterials with different dimensions, such as spherical nanoparticles and high-aspect-ratio nanotubes, may increase the target-specific antibacterial capacity of the consequent nanostructure while retaining an optimal biocompatibility. In this study, multi-walled carbon nanotubes (MWCNTs) were treated with a mixture of acids and decorated with Ag nanoparticles via a chemical reduction of Ag cations by ethanol solution. The synthesized Ag-MWCNT complexes were characterized by transmission electron microscopy, X-ray diffractometry, and energy-dispersive X-ray spectroscopy. The antibacterial function of Ag-MWCNTs was evaluated against Methylobacterium spp. and Sphingomonas spp. In addition, the biocompatibility of Ag-MWCNTs was evaluated using both mouse liver hepatocytes (AML 12) and human peripheral blood mononuclear cells. Finally, we determined the minimum amount of Ag-MWCNTs required for a biocompatible yet effective antibacterial treatment modality. We report that 30 μg/mL of Ag-MWCNTs confers antibacterial functionality while maintaining minimal cytotoxicity toward both human and animal cells. The results reported herein would be beneficial for researchers interested in the efficient preparation of hybrid nanostructures and in determining the minimum amount of Ag-MWCNTs necessary to effectively hinder the growth of bacteria. Dove Medical Press 2014-09-30 /pmc/articles/PMC4200021/ /pubmed/25336943 http://dx.doi.org/10.2147/IJN.S69561 Text en © 2014 Seo et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Seo, Youngmin Hwang, Jangsun Kim, Jieun Jeong, Yoon Hwang, Mintai P Choi, Jonghoon
spellingShingle	Seo, Youngmin Hwang, Jangsun Kim, Jieun Jeong, Yoon Hwang, Mintai P Choi, Jonghoon Antibacterial activity and cytotoxicity of multi-walled carbon nanotubes decorated with silver nanoparticles
author_facet	Seo, Youngmin Hwang, Jangsun Kim, Jieun Jeong, Yoon Hwang, Mintai P Choi, Jonghoon
author_sort	Seo, Youngmin
title	Antibacterial activity and cytotoxicity of multi-walled carbon nanotubes decorated with silver nanoparticles
title_short	Antibacterial activity and cytotoxicity of multi-walled carbon nanotubes decorated with silver nanoparticles
title_full	Antibacterial activity and cytotoxicity of multi-walled carbon nanotubes decorated with silver nanoparticles
title_fullStr	Antibacterial activity and cytotoxicity of multi-walled carbon nanotubes decorated with silver nanoparticles
title_full_unstemmed	Antibacterial activity and cytotoxicity of multi-walled carbon nanotubes decorated with silver nanoparticles
title_sort	antibacterial activity and cytotoxicity of multi-walled carbon nanotubes decorated with silver nanoparticles
description	Recently, various nanoscale materials, including silver (Ag) nanoparticles, have been actively studied for their capacity to effectively prevent bacterial growth. A critical challenge is to enhance the antibacterial properties of nanomaterials while maintaining their biocompatibility. The conjugation of multiple nanomaterials with different dimensions, such as spherical nanoparticles and high-aspect-ratio nanotubes, may increase the target-specific antibacterial capacity of the consequent nanostructure while retaining an optimal biocompatibility. In this study, multi-walled carbon nanotubes (MWCNTs) were treated with a mixture of acids and decorated with Ag nanoparticles via a chemical reduction of Ag cations by ethanol solution. The synthesized Ag-MWCNT complexes were characterized by transmission electron microscopy, X-ray diffractometry, and energy-dispersive X-ray spectroscopy. The antibacterial function of Ag-MWCNTs was evaluated against Methylobacterium spp. and Sphingomonas spp. In addition, the biocompatibility of Ag-MWCNTs was evaluated using both mouse liver hepatocytes (AML 12) and human peripheral blood mononuclear cells. Finally, we determined the minimum amount of Ag-MWCNTs required for a biocompatible yet effective antibacterial treatment modality. We report that 30 μg/mL of Ag-MWCNTs confers antibacterial functionality while maintaining minimal cytotoxicity toward both human and animal cells. The results reported herein would be beneficial for researchers interested in the efficient preparation of hybrid nanostructures and in determining the minimum amount of Ag-MWCNTs necessary to effectively hinder the growth of bacteria.
publisher	Dove Medical Press
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200021/
_version_	1613145803287691264

Antibacterial activity and cytotoxicity of multi-walled carbon nanotubes decorated with silver nanoparticles

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