Obstructive jaundice caused by intraductal metastasis of lung adenocarcinoma

Obstructive jaundice caused by metastases to the porta hepatis is often observed in patients with various advanced cancers; however, metastasis of lung cancer to the common bile duct with subsequent development of jaundice is rare. A 75-year-old female with lung adenocarcinoma harboring epidermal gr...

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Main Authors:	Ochi, Nobuaki, Goto, Daisuke, Yamane, Hiromichi, Yamagishi, Tomoko, Honda, Yoshihiro, Monobe, Yasumasa, Kawamoto, Hirofumi, Takigawa, Nagio
Format:	Online
Language:	English
Published:	Dove Medical Press 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199794/

id	pubmed-4199794
recordtype	oai_dc
spelling	pubmed-41997942014-10-21 Obstructive jaundice caused by intraductal metastasis of lung adenocarcinoma Ochi, Nobuaki Goto, Daisuke Yamane, Hiromichi Yamagishi, Tomoko Honda, Yoshihiro Monobe, Yasumasa Kawamoto, Hirofumi Takigawa, Nagio Case Report Obstructive jaundice caused by metastases to the porta hepatis is often observed in patients with various advanced cancers; however, metastasis of lung cancer to the common bile duct with subsequent development of jaundice is rare. A 75-year-old female with lung adenocarcinoma harboring epidermal growth factor receptor (EGFR) mutation (15-bp in-frame deletion in exon 19 and T790M in exon 20) developed obstructive jaundice during therapy. Obstruction of the common bile duct caused by an intraductal tumor was identified by computed tomography, endoscopic retrograde cholangiopancreatography, and endoscopic ultrasonography. Although primary cholangiocarcinoma was highly suspected according to the imaging findings, immunohistochemical evaluation of the intraductal tumor demonstrated thyroid transcription factor-1 positive adenocarcinoma. Furthermore, peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp analysis showed that the tumor contained the same EGFR mutation as that in the primary lung cancer. Thus, we confirmed intraductal metastasis from a lung adenocarcinoma. To our knowledge, this is the second report of obstructive jaundice caused by intraductal metastasis of lung cancer. Dove Medical Press 2014-10-07 /pmc/articles/PMC4199794/ /pubmed/25336976 http://dx.doi.org/10.2147/OTT.S68757 Text en © 2014 Ochi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ochi, Nobuaki Goto, Daisuke Yamane, Hiromichi Yamagishi, Tomoko Honda, Yoshihiro Monobe, Yasumasa Kawamoto, Hirofumi Takigawa, Nagio
spellingShingle	Ochi, Nobuaki Goto, Daisuke Yamane, Hiromichi Yamagishi, Tomoko Honda, Yoshihiro Monobe, Yasumasa Kawamoto, Hirofumi Takigawa, Nagio Obstructive jaundice caused by intraductal metastasis of lung adenocarcinoma
author_facet	Ochi, Nobuaki Goto, Daisuke Yamane, Hiromichi Yamagishi, Tomoko Honda, Yoshihiro Monobe, Yasumasa Kawamoto, Hirofumi Takigawa, Nagio
author_sort	Ochi, Nobuaki
title	Obstructive jaundice caused by intraductal metastasis of lung adenocarcinoma
title_short	Obstructive jaundice caused by intraductal metastasis of lung adenocarcinoma
title_full	Obstructive jaundice caused by intraductal metastasis of lung adenocarcinoma
title_fullStr	Obstructive jaundice caused by intraductal metastasis of lung adenocarcinoma
title_full_unstemmed	Obstructive jaundice caused by intraductal metastasis of lung adenocarcinoma
title_sort	obstructive jaundice caused by intraductal metastasis of lung adenocarcinoma
description	Obstructive jaundice caused by metastases to the porta hepatis is often observed in patients with various advanced cancers; however, metastasis of lung cancer to the common bile duct with subsequent development of jaundice is rare. A 75-year-old female with lung adenocarcinoma harboring epidermal growth factor receptor (EGFR) mutation (15-bp in-frame deletion in exon 19 and T790M in exon 20) developed obstructive jaundice during therapy. Obstruction of the common bile duct caused by an intraductal tumor was identified by computed tomography, endoscopic retrograde cholangiopancreatography, and endoscopic ultrasonography. Although primary cholangiocarcinoma was highly suspected according to the imaging findings, immunohistochemical evaluation of the intraductal tumor demonstrated thyroid transcription factor-1 positive adenocarcinoma. Furthermore, peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp analysis showed that the tumor contained the same EGFR mutation as that in the primary lung cancer. Thus, we confirmed intraductal metastasis from a lung adenocarcinoma. To our knowledge, this is the second report of obstructive jaundice caused by intraductal metastasis of lung cancer.
publisher	Dove Medical Press
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199794/
_version_	1613145744944922624

Obstructive jaundice caused by intraductal metastasis of lung adenocarcinoma

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