APOBEC3D and APOBEC3F Potently Promote HIV-1 Diversification and Evolution in Humanized Mouse Model

APOBEC3D and APOBEC3F Potently Promote HIV-1 Diversification and Evolution in Humanized Mouse Model

Several APOBEC3 proteins, particularly APOBEC3D, APOBEC3F, and APOBEC3G, induce G-to-A hypermutations in HIV-1 genome, and abrogate viral replication in experimental systems, but their relative contributions to controlling viral replication and viral genetic variation in vivo have not been elucidate...

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Bibliographic Details
Main Authors: Sato, Kei, Takeuchi, Junko S., Misawa, Naoko, Izumi, Taisuke, Kobayashi, Tomoko, Kimura, Yuichi, Iwami, Shingo, Takaori-Kondo, Akifumi, Hu, Wei-Shau, Aihara, Kazuyuki, Ito, Mamoru, An, Dong Sung, Pathak, Vinay K., Koyanagi, Yoshio
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199767/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199767/

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