Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice

Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice

DNA damage and telomere dysfunction shorten organismal lifespan. Here we show that oral glucose administration at advanced age increases health and lifespan of telomere dysfunctional mice. The study reveals that energy consumption increases in telomere dysfunctional cells resulting in enhanced gluco...

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Bibliographic Details
Main Authors: Missios, Pavlos, Zhou, Yuan, Guachalla, Luis Miguel, von Figura, Guido, Wegner, Andre, Chakkarappan, Sundaram Reddy, Binz, Tina, Gompf, Anne, Hartleben, Götz, Burkhalter, Martin D., Wulff, Veronika, Günes, Cagatay, Sattler, Rui Wang, Song, Zhangfa, Illig, Thomas, Klaus, Susanne, Böhm, Bernhard O., Wenz, Tina, Hiller, Karsten, Rudolph, K. Lenhard
Format: Online
Language:English
Published: Nature Pub. Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199114/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199114/

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