Novel unidirectional porous hydroxyapatite used as a bone substitute for open wedge high tibial osteotomy

Purpose: The purpose of this study was to clinically and radiologically evaluate the availability, osteoconductivity, and resorption of a novel unidirectional porous hydroxyapatite (UDPHAp) used as an artificial substitute for open wedge high tibial osteotomy (OWHTO). Our hypothesis was that UDPHAp...

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Main Authors:	Uemura, Kenta, Kanamori, Akihiro, Aoto, Katsuya, Yamazaki, Masashi, Sakane, Masataka
Format:	Online
Language:	English
Published:	Springer US 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198809/

id	pubmed-4198809
recordtype	oai_dc
spelling	pubmed-41988092014-10-21 Novel unidirectional porous hydroxyapatite used as a bone substitute for open wedge high tibial osteotomy Uemura, Kenta Kanamori, Akihiro Aoto, Katsuya Yamazaki, Masashi Sakane, Masataka Article Purpose: The purpose of this study was to clinically and radiologically evaluate the availability, osteoconductivity, and resorption of a novel unidirectional porous hydroxyapatite (UDPHAp) used as an artificial substitute for open wedge high tibial osteotomy (OWHTO). Our hypothesis was that UDPHAp is a safe and useful bone substitute for OWHTO. Materials and methods: Seven patients (2 men and 5 women aged 34-72years) who underwent OWHTO and were followed up for more than 12months were retrospectively studied. After the osteotomy, the gap created was filled with UDPHAp(REGENOS® Kuraray Co.Ltd). Radiography and computed tomography(CT) were performed, and gap healing was assessed postoperatively. The Japanese Orthopaedic Association (JOA) knee score was determined pre- and post-operatively for clinical evaluation. Results: Neither gross displacement nor collapse of the UDPHAp block graft was observed within 12 months after surgery. Both radiographs and CT showed attenuation of lucency and increasing sclerosis over time. JOA score improved from 71.2 (65−80) to 95.8 (85−100). Conclusions: Short term results for OWHTO using UDPHAp was satisfactory. Clinical improvement of JOA scores were seen, besides osteogenesis was progressing in and around the artificial bone grafts. Springer US 2014-07-05 2014 /pmc/articles/PMC4198809/ /pubmed/24997164 http://dx.doi.org/10.1007/s10856-014-5266-5 Text en © The Author(s) 2014 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Uemura, Kenta Kanamori, Akihiro Aoto, Katsuya Yamazaki, Masashi Sakane, Masataka
spellingShingle	Uemura, Kenta Kanamori, Akihiro Aoto, Katsuya Yamazaki, Masashi Sakane, Masataka Novel unidirectional porous hydroxyapatite used as a bone substitute for open wedge high tibial osteotomy
author_facet	Uemura, Kenta Kanamori, Akihiro Aoto, Katsuya Yamazaki, Masashi Sakane, Masataka
author_sort	Uemura, Kenta
title	Novel unidirectional porous hydroxyapatite used as a bone substitute for open wedge high tibial osteotomy
title_short	Novel unidirectional porous hydroxyapatite used as a bone substitute for open wedge high tibial osteotomy
title_full	Novel unidirectional porous hydroxyapatite used as a bone substitute for open wedge high tibial osteotomy
title_fullStr	Novel unidirectional porous hydroxyapatite used as a bone substitute for open wedge high tibial osteotomy
title_full_unstemmed	Novel unidirectional porous hydroxyapatite used as a bone substitute for open wedge high tibial osteotomy
title_sort	novel unidirectional porous hydroxyapatite used as a bone substitute for open wedge high tibial osteotomy
description	Purpose: The purpose of this study was to clinically and radiologically evaluate the availability, osteoconductivity, and resorption of a novel unidirectional porous hydroxyapatite (UDPHAp) used as an artificial substitute for open wedge high tibial osteotomy (OWHTO). Our hypothesis was that UDPHAp is a safe and useful bone substitute for OWHTO. Materials and methods: Seven patients (2 men and 5 women aged 34-72years) who underwent OWHTO and were followed up for more than 12months were retrospectively studied. After the osteotomy, the gap created was filled with UDPHAp(REGENOS® Kuraray Co.Ltd). Radiography and computed tomography(CT) were performed, and gap healing was assessed postoperatively. The Japanese Orthopaedic Association (JOA) knee score was determined pre- and post-operatively for clinical evaluation. Results: Neither gross displacement nor collapse of the UDPHAp block graft was observed within 12 months after surgery. Both radiographs and CT showed attenuation of lucency and increasing sclerosis over time. JOA score improved from 71.2 (65−80) to 95.8 (85−100). Conclusions: Short term results for OWHTO using UDPHAp was satisfactory. Clinical improvement of JOA scores were seen, besides osteogenesis was progressing in and around the artificial bone grafts.
publisher	Springer US
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198809/
_version_	1613145307645739008

Novel unidirectional porous hydroxyapatite used as a bone substitute for open wedge high tibial osteotomy

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