Current Status of Radical Prostatectomy for High-Risk Prostate Cancer

Current Status of Radical Prostatectomy for High-Risk Prostate Cancer

Despite the wide application of prostate-specific antigen-based screening leading to a profound stage migration in prostate cancer (PC), a significant percentage of men are still being diagnosed with clinically high-risk disease that requires aggressive treatment. Optimal management in these patient...

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Main Authors: Kang, Ho Won, Lee, Joo Yong, Kwon, Jong Kyou, Jeh, Seong Uk, Jung, Hae Do, Choi, Young Deuk
Format: Online
Language:English
Published: The Korean Urological Association 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198760/
id pubmed-4198760
recordtype oai_dc
spelling pubmed-41987602014-10-16 Current Status of Radical Prostatectomy for High-Risk Prostate Cancer Kang, Ho Won Lee, Joo Yong Kwon, Jong Kyou Jeh, Seong Uk Jung, Hae Do Choi, Young Deuk Review Article Despite the wide application of prostate-specific antigen-based screening leading to a profound stage migration in prostate cancer (PC), a significant percentage of men are still being diagnosed with clinically high-risk disease that requires aggressive treatment. Optimal management in these patients remains challenging, and strong advocates for radical prostatectomy (RP), radiotherapy, androgen deprivation therapy, and, increasingly, a multimodal approach abound. Currently, surgery for high-risk PC is frequently applied. RP offers an attractive opportunity for tumor excision either as a definitive management or as a first step in multimodal therapy. Nevertheless, this approach is still controversial. In this review, we discuss the current evidence for the role of RP in this clinical setting, including surgical considerations and outcomes. The role of robot-assisted RP, which is increasingly utilized in Korea in this clinical scenario, is discussed. The Korean Urological Association 2014-10 2014-10-10 /pmc/articles/PMC4198760/ /pubmed/25324944 http://dx.doi.org/10.4111/kju.2014.55.10.629 Text en © The Korean Urological Association, 2014 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Kang, Ho Won
Lee, Joo Yong
Kwon, Jong Kyou
Jeh, Seong Uk
Jung, Hae Do
Choi, Young Deuk
spellingShingle Kang, Ho Won
Lee, Joo Yong
Kwon, Jong Kyou
Jeh, Seong Uk
Jung, Hae Do
Choi, Young Deuk
Current Status of Radical Prostatectomy for High-Risk Prostate Cancer
author_facet Kang, Ho Won
Lee, Joo Yong
Kwon, Jong Kyou
Jeh, Seong Uk
Jung, Hae Do
Choi, Young Deuk
author_sort Kang, Ho Won
title Current Status of Radical Prostatectomy for High-Risk Prostate Cancer
title_short Current Status of Radical Prostatectomy for High-Risk Prostate Cancer
title_full Current Status of Radical Prostatectomy for High-Risk Prostate Cancer
title_fullStr Current Status of Radical Prostatectomy for High-Risk Prostate Cancer
title_full_unstemmed Current Status of Radical Prostatectomy for High-Risk Prostate Cancer
title_sort current status of radical prostatectomy for high-risk prostate cancer
description Despite the wide application of prostate-specific antigen-based screening leading to a profound stage migration in prostate cancer (PC), a significant percentage of men are still being diagnosed with clinically high-risk disease that requires aggressive treatment. Optimal management in these patients remains challenging, and strong advocates for radical prostatectomy (RP), radiotherapy, androgen deprivation therapy, and, increasingly, a multimodal approach abound. Currently, surgery for high-risk PC is frequently applied. RP offers an attractive opportunity for tumor excision either as a definitive management or as a first step in multimodal therapy. Nevertheless, this approach is still controversial. In this review, we discuss the current evidence for the role of RP in this clinical setting, including surgical considerations and outcomes. The role of robot-assisted RP, which is increasingly utilized in Korea in this clinical scenario, is discussed.
publisher The Korean Urological Association
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198760/
_version_ 1613145280023101440

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