A theoretical framework for the regulation of Shh morphogen-controlled gene expression
How morphogen gradients govern the pattern of gene expression in developing tissues is not well understood. Here, we describe a statistical thermodynamic model of gene regulation that combines the activity of a morphogen with the transcriptional network it controls. Using Sonic hedgehog (Shh) patter...
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Company of Biologists
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197706/ |